Continuous Monitoring Redox Nanosensors: The Next Step in Understanding Cancer Student: Christopher Kakidas Department: Pharmaceutical Sciences Advisor: Heather Clark Abstract The American public has been bombarded by commercials touting the positive effects of antioxidants and negative effects of oxidative free radicals of which the interplay is controlled by the reduction/oxidation (redox) state of the cell….
Category: Projects
Computationally Guided Protein-Specific Labeling with Nanoparticles
Computationally Guided Protein-Specific Labeling with Nanoparticles Student: Heather Brodkin Department: Chemistry Advisor: Mary Jo Ondrechen Abstract The Integrated Graduate Education Research and Training (IGERT) fellowship provides an excellent opportunity to combine our experimental and computational tools of chemical biology with nanotechnology, with a focus toward applications in nanomedicine. These applications include imaging, diagnostics, drug discovery…
Computationally Guided Ligand Design for the Human Adenosine A2A Receptor for Nanoparticle Imaging of Hypoxic Tumors
Computationally Guided Ligand Design for the Human Adenosine A2A Receptor for Nanoparticle Imaging of Hypoxic Tumors Student: Joslynn Lee Department: Chemistry Advisor: Mary Jo Ondrechen…
Combination Anticancer Nanopreparations of Novel Proapoptotic Drugs, TRAIL Ligand and siRNA
Combination Anticancer Nanopreparations of Novel Proapoptotic Drugs, TRAIL Ligand and siRNA Student: Bobby Riehle Department: Pharmaceutical Sciences Advisor: Vladimir Torchilin Abstract Cancer cells are known to use multiple pathways and mechanisms to promote survival and proliferation. In addition, some tumors are able to acquire resistance to various drugs over the course of treatment. As such,…
Collagen Single Fibril Mechanochemistry
Collagen Single Fibril Mechanochemistry Student: Brendan Flynn Department: Mechanical & Industrial Engineering Advisor: Jeffrey Ruberti Abstract Mechanical strain has been show to effect the enzymatic degradation of collagen. Single collagen fibrils are the fundamental units of connective tissue in mammals, and have yet to be probed mechanochemically. I am attaching individual collagen fibrils to a…
Application of Nanoarray Technologies to Spinal Stimulation and Regeneration: the Nano-BMI (brain-machine interface)
Student: Sucharita Saha Department: Biology Advisor: Donald O’Malley Abstract The purpose of this project is to design a nanowire interface to study the electrical properties of biological cells and tissues. The long term goal in fabricating this device, will be to evaluate the use of nanowire arrays to stimulate spinal regeneration and elicit locomotor movements…