Category: Projects

Implantable Nanoparticles Doped Brachytherapy Spacers for Synergistic Combinatorial Chemo-radiation Therapy in Prostate Cancer Student: Jodi Belz Department: Bioengineering Advisor: Sri Sridhar Abstract I use a nanoparticle based platforms for a control dual-release localized delivery of therapeutics in conjunction with radiation therapy in prostate cancer. This new approach involves the fabrication of inert spacers doped with…

Imaging of Embryonic Stem Cells using Multiphoton Luminescence of Gold Nanoparticles Student: Paula Lampton Department: Biology Advisor: Carol Warner Abstract Using the Keck 3D Fusion Microscope (located at Northeastern University), we were able to detect gold nanoparticles via multiphoton photoluminescence in mouse embryonic stem cells. The embryonic stem cells were able to grow for several…

High-Throughput Microfluidic Platform for Personalized Nanomedicine Student: Masoud Khabiry Department: Bioengineering Advisor: Nader Jalili Abstract Cancer remains as one of the leading causes of mortality worldwide, affecting over 10 million new patients every year. High-throughput studies of drug-loaded nanoparticles on patient derived cancer cells can be carried out in a novel and simple shear protected…

Enumerating Rare Cells Labeled with Fluorescent Nanoparticles Student: Stacey Markovic Department: Electrical and Computer Engineering Advisor: Mark Niedre…

Enhanced radiation therapy with location-selectively delivered nanoparticles Student: Autumn Paro Department: Chemical Engineering Advisor: Sri Sridhar…

Development of Dual-Targeted Liposomes for Delivery of Nucleic Acid Student: Bobby Riehle Department: Pharmaceutical Sciences Advisor: Vladimir Torchilin Abstract A novel cationic lipid based system for potential improved delivery of siRNA and DNA has been designed. Liposomes are modified with the cell surface targeting moieties Folic acid (FA) and Transferrin (TF). Many human cancers over-express…

Development of a Selective, Theranostic Nanoplatform to Inhibit Human Monoacylglycerol Lipase Student: Michael Johnson Department: Pharmaceutical Sciences Advisor: Alex Makriyannis Abstract: see biography….

Development of a Polymeric Nanoparticle Formulation to Overcome Multidrug Resistance of Cancer via a Multifunctional Therapy Student: Lilian van Vlerken Department: Pharmaceutical Sciences Advisor: Mansoor Amiji Abstract Nanotechnology is a very useful tool in the design of drug delivery systems to combat many diseases, where these nano-platforms can aide in target specific localization, controlled release,…

Determination of the sensitivity of collagen fibril formation to static and oscillatory strains Student: Brendan Flynn Department: Mechanical & Industrial Engineering Advisor: Jeffrey Ruberti Abstract It has been hypothesized that collagen is mechanosensitive material, with strain slowing enzymatic degradation and potentially increasing fibril formation. These theories are based on a number of findings where tension…

Design and Characterization of Multimeric RGD Peptidomimetics Conjugated Gold Nanoparticles for Tumor Diagnostic and Enhanced X-ray Radiotherapy Student: James Teh Department: Chemistry Advisor: Robert Hanson Abstract Gold nanoparticles (AuNPs) have unique physical and chemical properties appropriate for diagnostic and therapeutic applications in cancer. A novel approach is the use of AuNPs for radiotherapy, which upon…