Category: Projects

The Development of Fluorescent Glucose Nanosensors For In Vivo Glucose Monitoring

The Development of Fluorescent Glucose Nanosensors For In Vivo Glucose Monitoring Student: Kate Balaconis Department: Bioengineering Advisor: Heather Clark Abstract My project is the development and in vivo testing of fluorescent nanosensors for glucose monitoring. These nanosensors will provide a minimally-invasive method for monitoring glucose levels in diabetes. In our proposed system, the sensors will…

Targeted Nanocarriers

Targeted Nanocarriers Student: Tatyana Chernenko Department: Chemistry Advisor: Max Diem Abstract Non-invasive imaging techniques, such as Raman micro-spectral biochemical imaging techniques have been gaining recognition in the field of pharmaceutical research. It has the potential to provide not only the topographical sample information, but also morphological, biochemical data of a sample. We have applied this…

Targeted eNOS Gene Delivery with Lipopolyplexes for the Treatment of Coronary Restenosis

Targeted eNOS Gene Delivery with Lipopolyplexes for the Treatment of Coronary Restenosis Student: Luis Brito Department: Pharmaceutical Sciences Advisor: Mansoor Amiji Abstract The main thrust of this research is to develop gene therapy strategy using safe and effective non-viral vectors for local production of endothelial nitric oxide synthase (eNOS) on arterial wall. Local eNOS production…

Targeted Delivery of a Mitochondriotropic Apoptosis Modulator Using Multifunctional Polymeric Nanoparticles for the Treatment of Drug Resistant Tumors

Targeted Delivery of a Mitochondriotropic Apoptosis Modulator Using Multifunctional Polymeric Nanoparticles for the Treatment of Drug Resistant Tumors Student: Lara Milane Department: Pharmaceutical Sciences Advisor: Mansoor Amiji Abstract Mitochondria are well recognized as the central organelles of energy production and the apoptotic pathway. Mitochondrial dysfunction contributes to the pathogenesis of a multitude of conditions including…

Synthesis of Spin Labeled Nanosensors for the Estrogen Receptor

Synthesis of Spin Labeled Nanosensors for the Estrogen Receptor Student: Adam Hendricks Department: Chemistry Advisor: Robert Hanson Abstract Since the term “nanotechnology” was introduced in 1986 by Eric Drexler, it has grown to include a variety of disciplines; such as medicine. The goal of my research is to apply nanotechnology to the field of medicinal…

Synthesis of Nanoencapsulated Aminoglycosides as Small-Molecule Gene Therapeutics

Synthesis of Nanoencapsulated Aminoglycosides as Small-Molecule Gene Therapeutics Student: Michael Cuccarese Department: Chemistry Advisor: George O’Doherty Abstract Aminoglycosides are a class of broad-spectrum antibiotics. Neomycin is the active ingredient in the topical antibiotic Neosporin and other aminoglycosides, such as Kanamycin and Gentamicin, are regularly used to treat life-threatening bacterial infections. The bad news is that…

Site-Specific delivery of anti-infective therapies in neglected tropical diseases using nano-sized formulations

Site-Specific delivery of anti-infective therapies in neglected tropical diseases using nano-sized formulations Student: Jennifer Woodring Department: Chemistry Advisor: Michael Pollastri Abstract Neglected tropical diseases are comprised of 13 parasitic and bacterial diseases. They put 2.7 billion of the world’s population at risk and their disability adjusted life years outnumber well known diseases like malaria and…