Biomolecular Sequence Quantification Using Magnetic Nanoparticles With a Giant Magnetoresistive (GMR) Sensor Student: Dino Buro Department: Electrical and Computer Engineering Advisor: Abstract My project utilizes magnetic nanoparticles to capture, or tag, strands of interest DNA. These strands are mixed with an abundance of probe DNA strands at the surface of a GMR sensor. Weakly bonded…
Category: Projects
Au Nanowire Arrays for Stimulating and Detecting Electrical Activity in Neuronal Cells
Au Nanowire Arrays for Stimulating and Detecting Electrical Activity in Neuronal Cells Student: Jesse Silverberg Department: Physics Advisor: Latika Menon Abstract The process of anodization is used to fabricate a nanoporous template. This template has a hexagonally packed arrangement of cylindrical pores with controllable features such as pore diameter and length. By electrochemical means, Au…
An Analysis of the Effect of PEG on Physical Properties of Cationic Liposomes Intended for Gene Therapy
An Analysis of the Effect of PEG on Physical Properties of Cationic Liposomes Intended for Gene Therapy Student: Marshall Brooks Department: Pharmaceutical Sciences Advisor: Abstract The goal of this study is to determine whether PEGylated cationic liposomes (nanodelivery system) are more avidly taken up by brain cancer cells (U-87 MG) compared to non-PEGylated cationic lipsomes…
Alumina Templates
Alumina Templates Student: Cory Fantasia Department: Physics Advisor: Sri Sridhar Abstract Anodized aluminum is formed by using a piece of aluminum metal as the positive electrode in a circuit. In this process, aluminum oxide (alumina) is formed on top of the aluminum. This layer contains an array of pores that grow perpendicular to the aluminum…
Visualization and Enhancement of Spinal Cord Regeneration using Nanoparticles
Visualization and Enhancement of Spinal Cord Regeneration using Nanoparticles Student: Sucharita Saha Department: Biology Advisor: Donald O’Malley Abstract The goal of this project is to employ functionalized nanoparticles to evaluate the feasibility of delivering DNA- or RNA-functionalized nanoparticles to brainstem neurons damaged in spinal cord injury. We will visualize the expression of exogenous neural repair…
Using Nanoparticles to Analyze Key Immune System Molecules in Embryonic Stem Cells
Using Nanoparticles to Analyze Key Immune System Molecules in Embryonic Stem Cells Student: Paula Lampton Department: Biology Advisor: Carol Warner Abstract The goal of my IGERT thesis project is to characterize the expression and localization of MHC class I molecules in embryonic stem cells. Embryonic stem cells are pluripotent cells capable of unlimited self renewal…
Use of nanotechnology for imaging of cell surface oligosaccharides for early diagnosis of cancer
Use of nanotechnology for imaging of cell surface oligosaccharides for early diagnosis of cancer Student: Agnes Rafalko Department: Chemistry Advisor: William Hancock Abstract Glycosylation is one of the most common post-translational modifications for human and other eukaryotic proteins and is required for many proteins to fold to the correct 3-dimensional structure and thus achieve full…
Understanding optical properties of nanoparticles towards application with biospecific markers for pre-cancer detection
Understanding optical properties of nanoparticles towards application with biospecific markers for pre-cancer detection Student: Yogesh G Patel Department: Electrical and Computer Engineering Advisor: Charles Di Marzio Abstract Among skin malignancies, basal cell carcinoma (BCC) is the most common, occurring at an estimated rate of 800,000 cases in the United States every year costing $500 million/year….
Tumor Hypoxia, the Warburg Effect, and Multidrug Resistance: Modulation of Hypoxia Induced MDR Using EGFR Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Therapy
Tumor Hypoxia, the Warburg Effect, and Multidrug Resistance: Modulation of Hypoxia Induced MDR Using EGFR Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Therapy Student: Lara Milane Department: Pharmaceutical Sciences Advisor: Mansoor Amiji Abstract The clinical focus of Lara’s work is Multi-Drug Resistant (MDR) cancer. MDR cancer is most often implicated in cases of recurrent, non-responsive…
The Mechanosensitivity of Type I Collagen to MMP Cleavage
The Mechanosensitivity of Type I Collagen to MMP Cleavage Student: Robert Camp Department: Mechanical & Industrial Engineering Advisor: Jeffrey Ruberti Abstract In general, the goal will be to quantify collagen’s mechanosensitivity to enzymatic cleavage by MMPs. Data such as the time to cleavage as a function of mechanical load, enzyme bonding, and cleavage force kinetics…